Human Papillomavirus Species-Specific Interaction with the Basement Membrane-Resident Non-Heparan Sulfate Receptor

Human Papillomavirus Species-Specific Interaction with the Basement Membrane-Resident Non-Heparan Sulfate Receptor

Using a cell culture model where virus is bound to the extracellular matrix (ECM) prior to cell surface binding, we determined that human papillomavirus type 16 (HPV16) utilizes ECM resident laminin (LN) 332 as an attachment receptor for infectious entry. In presence of LN332, soluble heparin can fu...

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Bibliographic Details
Main Authors: Kathleen F. Richards, Santanu Mukherjee, Malgorzata Bienkowska-Haba, Jia Pang, Martin Sapp
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:Viruses
Subjects:
HPV
extracellular matrix
heparan sulfate
laminin 332
receptor
entry
Online Access:http://www.mdpi.com/1999-4915/6/12/4856

Internet

http://www.mdpi.com/1999-4915/6/12/4856

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