Pharmacokinetics and safety evaluation of intravenously administered Pseudomonas phage PA_LZ7 in a mouse model

Pharmacokinetics and safety evaluation of intravenously administered Pseudomonas phage PA_LZ7 in a mouse model

ABSTRACT Phage therapy has become one of the most promising alternatives to antibiotics as the surge of multi-drug-resistant (MDR) bacteria severely threatens global public health. The lack of a thorough understanding of pharmacokinetics (PK) and the safety study of phage has limited its clinical ap...

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Bibliographic Details
Main Authors: Si-yun Wang, Xin Tan, Zi-qiang Liu, Hui Ma, Tian-bin Liu, Yong-qing Yang, Yong Ying, Ru-yue Gao, Dai-zhou Zhang, Ying-fei Ma, Kai Chen, Lin Lin, Zhi-huan Jiang, Jia-lin Yu
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:Microbiology Spectrum
Subjects:
phage therapy
safety
antibiotic resistance
pharmacokinetics
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01882-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.01882-23

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