A Novel Method to Construct 2-Aminobenzofurans via [4 + 1] Cycloaddition Reaction of In Situ Generated <i>Ortho</i>-Quinone Methides with Isocyanides

A Novel Method to Construct 2-Aminobenzofurans via [4 + 1] Cycloaddition Reaction of In Situ Generated <i>Ortho</i>-Quinone Methides with Isocyanides

A new approach for the synthesis of 2-aminobenzofurans has been described via Sc(OTf)<sub>3</sub> mediated formal cycloaddition of isocyanides with the in situ generated <i>ortho</i>-quinone methides (<i>o</i>-QMs) from <i>o</i>-hydroxybenzhydryl alcoh...

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Bibliographic Details
Main Authors: Huaxin Lin, Senling Tang, Yang Pan, Peng Liang, Xiaofeng Ma, Wei Jiao, Huawu Shao
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
2-aminobenzofurans
isocyanides
<i>ortho</i>-quinone methides
[4 + 1] cycloaddition
Online Access:https://www.mdpi.com/1420-3049/27/23/8538

Internet

https://www.mdpi.com/1420-3049/27/23/8538

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