Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium

Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium

Here Kim et al. show that primary BMECs can be maintained ex vivo as distinct sinusoidal- and arterial-like populations and that the presence of macrophages is critical to preserve their native transcriptomic profiles and functional heterogeneity.

Bibliographic Details
Main Authors: Young-Woong Kim, Greta Zara, HyunJun Kang, Sergio Branciamore, Denis O’Meally, Yuxin Feng, Chia-Yi Kuan, Yingjun Luo, Michael S. Nelson, Alex B. Brummer, Russell Rockne, Zhen Bouman Chen, Yi Zheng, Angelo A. Cardoso, Nadia Carlesso
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34425-z

Internet

https://doi.org/10.1038/s41467-022-34425-z

Similar Items