CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst

CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst

Highlights Fatty acid metabolism and CPT1A in AgRP neurons show marked sex-dependent differences in the control of feeding. Cpt1a gene deletion in AgRP neurons increases energy expenditure in females but not in males. CPT1A in AgRP neurons is involved in the control of thirst and fluid homeostasis....

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Bibliographic Details
Main Authors: Sebastián Zagmutt, Paula Mera, Ismael González-García, Kevin Ibeas, María del Mar Romero, Arnaud Obri, Beatriz Martin, Anna Esteve-Codina, M. Carmen Soler-Vázquez, Marianela Bastias-Pérez, Laia Cañes, Elisabeth Augé, Carme Pelegri, Jordi Vilaplana, Xavier Ariza, Jordi García, José Martinez-González, Núria Casals, Miguel López, Richard Palmiter, Elisenda Sanz, Albert Quintana, Laura Herrero, Dolors Serra
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Biology of Sex Differences
Subjects:
CPT1A
Fatty acid metabolism
AgRP neurons
Energy balance
Food intake
Thirst
Online Access:https://doi.org/10.1186/s13293-023-00498-8

Internet

https://doi.org/10.1186/s13293-023-00498-8

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