Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells

Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells

Recent data establish a logarithmic expansion of leucine rich repeat containing G protein coupled receptor 5–positive (Lgr5+) colonic epithelial stem cells (CESCs) in human colorectal cancer (CRC). Complementary studies using the murine 2-stage azoxymethane–dextran sulfate sodium (AOM-DSS) colitis-a...

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Bibliographic Details
Main Authors: Stefan Klingler, Kuo-Shun Hsu, Guoqiang Hua, Maria Laura Martin, Mohammad Adileh, Timour Baslan, Zhigang Zhang, Philip B. Paty, Zvi Fuks, Anthony M.C. Brown, Richard Kolesnick
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-03-01
Series:JCI Insight
Subjects:
Oncology
Stem cells
Online Access:https://doi.org/10.1172/jci.insight.153793

Internet

https://doi.org/10.1172/jci.insight.153793

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