Ethanol yield improvement in Saccharomyces cerevisiae GPD2 Delta FPS1 Delta ADH2 Delta DLD3 Delta mutant and molecular mechanism exploration based on the metabolic flux and transcriptomics approaches

Ethanol yield improvement in Saccharomyces cerevisiae GPD2 Delta FPS1 Delta ADH2 Delta DLD3 Delta mutant and molecular mechanism exploration based on the metabolic flux and transcriptomics approaches

Abstract Background Saccharomyces cerevisiae generally consumes glucose to produce ethanol accompanied by the main by-products of glycerol, acetic acid, and lactic acid. The minimization of the formation of by-products in S. cerevisiae was an effective way to improve the economic viability of the bi...

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Bibliographic Details
Main Authors: Peizhou Yang, Shuying Jiang, Shuhua Lu, Suwei Jiang, Shaotong Jiang, Yanhong Deng, Jiuling Lu, Hu Wang, Yong Zhou
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Microbial Cell Factories
Subjects:
Engineered Saccharomyces cerevisiae
Ethanol production
Gene knock-out
CRISPR-Cas9
Transcriptomics analysis
Metabolic flux
Online Access:https://doi.org/10.1186/s12934-022-01885-3

Internet

https://doi.org/10.1186/s12934-022-01885-3

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