A transcriptomic analysis of cerebral microvessels reveals the involvement of Notch1 signaling in endothelial mitochondrial-dysfunction-dependent BBB disruption

A transcriptomic analysis of cerebral microvessels reveals the involvement of Notch1 signaling in endothelial mitochondrial-dysfunction-dependent BBB disruption

Abstract Background Endothelial cells (ECs) in cerebral vessels are considered the primary targets in acute hemorrhagic brain injuries. EC dysfunction can aggravate neuronal injuries by causing secondary inflammatory responses and blood–brain barrier (BBB) disruption. Previous studies have reported...

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Bibliographic Details
Main Authors: Min Joung Lee, Jiebo Zhu, Jong Hun An, Seong Eun Lee, Tae Yeon Kim, Eungseok Oh, Yea Eun Kang, Woosuk Chung, Jun Young Heo
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood–brain barrier
Endothelial cell
Mitochondria
Intracellular stroke
Online Access:https://doi.org/10.1186/s12987-022-00363-7

Internet

https://doi.org/10.1186/s12987-022-00363-7

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