Transcriptome comparisons of in vitro intestinal epithelia grown under static and microfluidic gut-on-chip conditions with in vivo human epithelia

Abstract Gut-on-chip devices enable exposure of cells to a continuous flow of culture medium, inducing shear stresses and could thus better recapitulate the in vivo human intestinal environment in an in vitro epithelial model compared to static culture methods. We aimed to study if dynamic culture c...

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Bibliographic Details
Main Authors: Kornphimol Kulthong, Guido J. E. J. Hooiveld, Loes Duivenvoorde, Ignacio Miro Estruch, Victor Marin, Meike van der Zande, Hans Bouwmeester
Format: Article
Language:English
Published: Nature Portfolio 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-82853-6