Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration

Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration

Abstract Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics, and currently used drugs cannot reverse the disease progress. Worse still, there are still challenges to be addressed to fully decipher the intricated pathogenesis. Thus, specifying the essential...

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Bibliographic Details
Main Authors: Mingyao Wang, Zhe Zhang, Jiangfeng Liu, Meiyue Song, Tiantian Zhang, Yiling Chen, Huiyuan Hu, Peiran Yang, Bolun Li, Xiaomin Song, Junling Pang, Yanjiang Xing, Zhujie Cao, Wenjun Guo, Hao Yang, Jing Wang, Juntao Yang, Chen Wang
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-00959-3

Internet

https://doi.org/10.1038/s41392-022-00959-3

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