Structural visualization of key steps in nucleosome reorganization by human FACT
Abstract Facilitates chromatin transcription (FACT) is a histone chaperone, which accomplishes both nucleosome assembly and disassembly. Our combined cryo-electron microscopy (EM) and native mass spectrometry (MS) studies revealed novel key steps of nucleosome reorganization conducted by a Mid domai...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2019-07-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-019-46617-7 |