Characterization of the Jomthonic Acids Biosynthesis Pathway and Isolation of Novel Analogues in Streptomyces caniferus GUA-06-05-006A

Characterization of the Jomthonic Acids Biosynthesis Pathway and Isolation of Novel Analogues in Streptomyces caniferus GUA-06-05-006A

Jomthonic acids (JAs) are a group of natural products (NPs) with adipogenic activity. Structurally, JAs are formed by a modified β-methylphenylalanine residue, whose biosynthesis involves a methyltransferase that in Streptomyces hygroscopicus has been identified as MppJ. Up to date, three JA members...

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Bibliographic Details
Main Authors: Raúl García-Salcedo, Rubén Álvarez-Álvarez, Carlos Olano, Librada Cañedo, Alfredo F. Braña, Carmen Méndez, Fernando de la Calle, José A. Salas
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Marine Drugs
Subjects:
biosynthesis gene cluster
molecular elicitation
heterologous expression
polyketide synthase
nonribosomal peptide synthetase
Online Access:http://www.mdpi.com/1660-3397/16/8/259

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http://www.mdpi.com/1660-3397/16/8/259

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