Fisetin inhibits human melanoma cell invasion through promotion of mesenchymal to epithelial transition and by targeting MAPK and NFκB signaling pathways.

Fisetin inhibits human melanoma cell invasion through promotion of mesenchymal to epithelial transition and by targeting MAPK and NFκB signaling pathways.

Malignant melanoma is responsible for approximately 75% of skin cancer-related deaths. BRAF plays an important role in regulating the mitogen-activated protein kinase (MAPK) signaling cascade in melanoma with activating mutations in the serine/threonine kinase BRAF occurring in 60-70% of malignant m...

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Bibliographic Details
Main Authors: Harish Chandra Pal, Samriti Sharma, Leah Ray Strickland, Santosh K Katiyar, Mary E Ballestas, Mohammad Athar, Craig A Elmets, Farrukh Afaq
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3900533?pdf=render

Internet

http://europepmc.org/articles/PMC3900533?pdf=render

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