Anoctamin 1 Inhibition Suppresses Cystogenesis by Enhancing Ciliogenesis and the Ciliary Dosage of Polycystins

Anoctamin 1 Inhibition Suppresses Cystogenesis by Enhancing Ciliogenesis and the Ciliary Dosage of Polycystins

Background: Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized by abnormal tubular epithelial proliferation and fluid secretion. Anoctamin 1 (ANO1) is a calcium-dependent chloride channel. However, how ANO1 contributes to ADPKD is largely unexplored. Methods: Kidney t...

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Bibliographic Details
Main Authors: Tao Xu, Meihan Chen, Qingwen Xu, Cheng Xue, Lili Fu, Kun Ling, Jinghua Hu, Changlin Mei
Format: Article
Language:English
Published: IMR Press 2022-07-01
Series:Frontiers in Bioscience-Landmark
Subjects:
autosomal dominant polycystic kidney disease
anoctamin 1
primary cilium
polycystin
Online Access:https://www.imrpress.com/journal/FBL/27/7/10.31083/j.fbl2707216

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https://www.imrpress.com/journal/FBL/27/7/10.31083/j.fbl2707216

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