ON THE PRO-METASTATIC STRESS RESPONSE TO CANCER THERAPIES: EVIDENCE FOR A POSITIVE CO-OPERATION BETWEEN TIMP-1, HIF-1α, AND miR-210

ON THE PRO-METASTATIC STRESS RESPONSE TO CANCER THERAPIES: EVIDENCE FOR A POSITIVE CO-OPERATION BETWEEN TIMP-1, HIF-1α, AND miR-210

In contrast to expectations in the past that tumor starvation or unselective inhibition of proteolytic activity would cure cancer, there is accumulating evidence that microenvironmental stress, such as hypoxia or broad spectrum inhibition of metalloproteinases can promote metastasis. In fact, malign...

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Bibliographic Details
Main Authors: Haissi eCui, Sebastien eGrosso, Florian eSchelter, Bernard eMari, Achim eKrüger
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Pharmacology
Subjects:
microRNA
microenvironment
Met
MMP
HIF-1α
miR-210
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00134/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00134/full

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