GENE-IS: Time-Efficient and Accurate Analysis of Viral Integration Events in Large-Scale Gene Therapy Data

GENE-IS: Time-Efficient and Accurate Analysis of Viral Integration Events in Large-Scale Gene Therapy Data

Integration site profiling and clonality analysis of viral vector distribution in gene therapy is a key factor to monitor the fate of gene-corrected cells, assess the risk of malignant transformation, and establish vector biosafety. We developed the Genome Integration Site Analysis Pipeline (GENE-IS...

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Bibliographic Details
Main Authors: Saira Afzal, Stefan Wilkening, Christof von Kalle, Manfred Schmidt, Raffaele Fronza
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116303638

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http://www.sciencedirect.com/science/article/pii/S2162253116303638

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