FORGEdb: a tool for identifying candidate functional variants and uncovering target genes and mechanisms for complex diseases

FORGEdb: a tool for identifying candidate functional variants and uncovering target genes and mechanisms for complex diseases

Abstract The majority of disease-associated variants identified through genome-wide association studies are located outside of protein-coding regions. Prioritizing candidate regulatory variants and gene targets to identify potential biological mechanisms for further functional experiments can be cha...

Full description

Bibliographic Details
Main Authors: Charles E. Breeze, Eric Haugen, María Gutierrez-Arcelus, Xiaozheng Yao, Andrew Teschendorff, Stephan Beck, Ian Dunham, John Stamatoyannopoulos, Nora Franceschini, Mitchell J. Machiela, Sonja I. Berndt
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Genome Biology
Subjects:
Gene regulation
Functional annotation
Variant scoring
Regulatory elements
Genome-wide association study (GWAS)
Expression quantitative trait locus (eQTL)
Online Access:https://doi.org/10.1186/s13059-023-03126-1

Internet

https://doi.org/10.1186/s13059-023-03126-1

Similar Items