IgTreeZ, A Toolkit for Immunoglobulin Gene Lineage Tree-Based Analysis, Reveals CDR3s Are Crucial for Selection Analysis

IgTreeZ, A Toolkit for Immunoglobulin Gene Lineage Tree-Based Analysis, Reveals CDR3s Are Crucial for Selection Analysis

Somatic hypermutation (SHM) is an important diversification mechanism that plays a part in the creation of immune memory. Immunoglobulin (Ig) variable region gene lineage trees were used over the last four decades to model SHM and the selection mechanisms operating on B cell clones. We hereby presen...

Full description

Bibliographic Details
Main Authors: Hadas Neuman, Jessica Arrouasse, Meirav Kedmi, Andrea Cerutti, Giuliana Magri, Ramit Mehr
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
antibody
B cell receptor (BCR)
B cell repertoire
immunoglobulin
lineage tree
somatic hypermutation (SHM)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.822834/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.822834/full

Similar Items