Notch activation defines immune-suppressive subsets of ccRCCs with unfavorable benefits from immunotherapy over VEGFR/mTOR inhibitors

Notch activation defines immune-suppressive subsets of ccRCCs with unfavorable benefits from immunotherapy over VEGFR/mTOR inhibitors

Summary: The evolutionarily conserved Notch pathway, involved in cancer stem cell capacity and cancer immunity, may predict the benefit from immune checkpoint inhibitors (ICIs) in clear cell renal cell carcinoma (ccRCC). In the TCGA dataset, mRNA expression of Notch pathway genes identified three cl...

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Bibliographic Details
Main Authors: Sujun Han, Yu Xu, Dong Chen, Feiya Yang, Mingshuai Wang, Qiaoxia Zhou, Guoqiang Wang, Leo Li, Chunwei Xu, Wenxian Wang, Shangli Cai, Nianzeng Xing
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:iScience
Subjects:
Health sciences
Gene ontology
Molecular biology
Immunology
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223023672

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http://www.sciencedirect.com/science/article/pii/S2589004223023672

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