An unfolded protein response (UPR)-signature regulated by the NFKB–miR-29b/c axis fosters tumor aggressiveness and poor survival in bladder cancer

An unfolded protein response (UPR)-signature regulated by the NFKB–miR-29b/c axis fosters tumor aggressiveness and poor survival in bladder cancer

BackgroundBladder cancer continues to pose a substantial global health challenge, marked by a high mortality rate despite advances in treatment options. Therefore, in-depth understanding of molecular mechanisms related to disease onset, progression, and patient survival is of utmost importance in bl...

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Bibliographic Details
Main Authors: Jian Zhang, Xiaosong Fan, Yu Chen, Yichao Han, Weixing Yu, Shaolin Zhang, Bicheng Yang, Junlong Zhang, Yanling Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
bladder cancer
ER stress
UPR
inflammation
NFkB
miR-29b/c
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1542650/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2025.1542650/full

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