Influence of Polyvinylpyrrolidone Molecular Weight and Concentration on the Precipitation Inhibition of Supersaturated Solutions of Poorly Soluble Drugs

Influence of Polyvinylpyrrolidone Molecular Weight and Concentration on the Precipitation Inhibition of Supersaturated Solutions of Poorly Soluble Drugs

Supersaturating drug delivery systems such as solid dispersions of a drug in a polymer are frequently used in pharmaceutical development to enable oral delivery of poorly soluble drugs. In this study, the influence of the concentration and molecular weight of polyvinylpyrrolidone (PVP) on the precip...

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Bibliographic Details
Main Authors: Afnan Bany Odeh, Boushra El-Sayed, Matthias Manne Knopp, Thomas Rades, Lasse Ingerslev Blaabjerg
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceutics
Subjects:
supersaturation
nucleation
crystal growth
polymer
precipitation inhibitor
solvent-shift method
Online Access:https://www.mdpi.com/1999-4923/15/6/1601

Internet

https://www.mdpi.com/1999-4923/15/6/1601

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