DNase 1 Protects From Increased Thrombin Generation and Venous Thrombosis During Aging: Cross‐Sectional Study in Mice and Humans

DNase 1 Protects From Increased Thrombin Generation and Venous Thrombosis During Aging: Cross‐Sectional Study in Mice and Humans

Background Human aging is associated with increased risk of thrombosis, but the mechanisms are poorly defined. We hypothesized that aging induces peroxide‐dependent release of neutrophil extracellular traps that contribute to thrombin generation and thrombosis. Methods and Results We studied C57BL6J...

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Bibliographic Details
Main Authors: Rahul Kumar, Vijay K. Sonkar, Jagadish Swamy, Azaj Ahmed, Anjali A. Sharathkumar, Gary L. Pierce, Sanjana Dayal
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
age
aging
extracellular traps
oxidative stress
thrombosis
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.021188

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.021188

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