Staphylococcus aureus Cell Wall Biosynthesis Modulates Bone Invasion and Osteomyelitis Pathogenesis

Staphylococcus aureus Cell Wall Biosynthesis Modulates Bone Invasion and Osteomyelitis Pathogenesis

Staphylococcus aureus invasion of the osteocyte lacuno-canalicular network (OLCN) is a novel mechanism of bacterial persistence and immune evasion in chronic osteomyelitis. Previous work highlighted S. aureus cell wall transpeptidase, penicillin binding protein 4 (PBP4), and surface adhesin, S. aure...

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Bibliographic Details
Main Authors: Elysia A. Masters, Gowrishankar Muthukrishnan, Lananh Ho, Ann Lindley Gill, Karen L. de Mesy Bentley, Chad A. Galloway, James L. McGrath, Hani A. Awad, Steven R. Gill, Edward M. Schwarz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Microbiology
Subjects:
S. aureus
osteomyelitis
cell wall
PBP 3
autolysin
surface adhesion
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.723498/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.723498/full

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