A pilot study of oral treprostinil pharmacogenomics and treatment persistence in patients with pulmonary arterial hypertension

Background and aims: Treprostinil is a prostacyclin analog used to treat pulmonary arterial hypertension. Dosing is empiric and based on tolerability. Adverse effects are common and can affect treatment persistence. Pharmacogenomic variants that may affect treprostinil metabolism and transport have...

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Bibliographic Details
Main Authors: James C. Coons, Karryn Crisamore, Solomon Adams, Ashley Modany, Marc A. Simon, Wenchen Zhao, Imam H. Shaik, Raman Venkataramanan, Philip E. Empey
Format: Article
Language:English
Published: SAGE Publishing 2021-04-01
Series:Therapeutic Advances in Respiratory Disease
Online Access:https://doi.org/10.1177/17534666211013688