Detection of pathogenic variants in Alzheimer’s disease related genes in Bulgarian patients by pooled whole-exome sequencing

Detection of pathogenic variants in Alzheimer’s disease related genes in Bulgarian patients by pooled whole-exome sequencing

In an effort to better understand the complex genetic background of Alzheimer’s disease (AD) we performed high-coverage whole-exome sequencing of a DNA pool assembled of 66 Bulgarian AD patients. We focused our analysis on genes demonstrated to have association with AD in previous studies, i.e. PSEN...

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Bibliographic Details
Main Authors: Sena Karachanak-Yankova, Dimitar Serbezov, Marta Mihaylova, Dragomira Nikolova, Lubomir Balabanski, Vera Damyanova, Olga Antonova, Rada Staneva, Mihail Ganev, Victoria Spasova, Blaga Rukova, Desislava Nesheva, Slavica Josifovska, Mikaela Stancheva, Diana Belejanska, Mariya Petrova, Shima Mehrabian, Latchezar Traykov, Savina Hadjidekova, Draga Toncheva
Format: Article
Language:English
Published: Taylor & Francis Group 2023-03-01
Series:Biotechnology & Biotechnological Equipment
Subjects:
Alzheimer’s disease
pathogenic variants
pool-seq analysis
Bulgarian population
Online Access:https://www.tandfonline.com/doi/10.1080/13102818.2022.2155572

Internet

https://www.tandfonline.com/doi/10.1080/13102818.2022.2155572

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