New Analogs of Polyamine Toxins from Spiders and Wasps: Liquid Phase Fragment Synthesis and Evaluation of Antiproliferative Activity

New Analogs of Polyamine Toxins from Spiders and Wasps: Liquid Phase Fragment Synthesis and Evaluation of Antiproliferative Activity

Polyamine toxins (PATs) are conjugates of polyamines (PAs) with lipophilic carboxylic acids, which have been recently shown to present antiproliferative activity. Ten analogs of the spider PATs <b>Agel 416</b>, <b>HO-416b</b>, and JSTX-3 and the wasp PAT PhTX-433 were synthes...

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Bibliographic Details
Main Authors: Christos Vassileiou, Stefania Kalantzi, Eleanna Vachlioti, Constantinos M. Athanassopoulos, Christos Koutsakis, Zoi Piperigkou, Nikos Karamanos, Theodora Stivarou, Peggy Lymberi, Konstantinos Avgoustakis, Dionissios Papaioannou
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
polyamine toxins
polyamines
lipophilic head groups
hydroxy amino acids
(indol-3-yl)acetic acid
propargylglycine
Online Access:https://www.mdpi.com/1420-3049/27/2/447

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https://www.mdpi.com/1420-3049/27/2/447

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