High sulfation and a high molecular weight are important for anti-hepcidin activity of heparin

High sulfation and a high molecular weight are important for anti-hepcidin activity of heparin

Heparins are efficient inhibitors of hepcidin expression even in vivo, where they induce an increase of systemic iron availability. Heparins seem to act by interfering with BMP6 signaling pathways that control the expression of liver hepcidin, causing the suppression of SMAD1/5/8 phosphorylation. Th...

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Bibliographic Details
Main Authors: Michela eAsperti, Annamaria eNaggi, Emiliano eEsposito, Paola eRuzzenenti, Margherita eDi Somma, Magdalena eGryzik, Paolo eArosio, Maura ePoli
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Pharmacology
Subjects:
iron metabolism
hepcidin
anemia of chronic diseases
BMP6
Low molecular weight heparins
2-O and 6-O sulfated heparins
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00316/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00316/full

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