Transcriptional Repression of Ferritin Light Chain Increases Ferroptosis Sensitivity in Lung Adenocarcinoma

Transcriptional Repression of Ferritin Light Chain Increases Ferroptosis Sensitivity in Lung Adenocarcinoma

Ferroptosis is an iron- and lipid peroxidation-dependent form of regulated cell death. The release of labile iron is one of the important factors affecting sensitivity to ferroptosis. Yes-associated protein (YAP) controls intracellular iron levels by affecting the transcription of ferritin heavy cha...

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Bibliographic Details
Main Authors: Yikun Wang, Shiyu Qiu, Hong Wang, Jiangtao Cui, Xiaoting Tian, Yayou Miao, Congcong Zhang, Leiqun Cao, Lifang Ma, Xin Xu, Yongxia Qiao, Xiao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
YAP
TFCP2
erastin
labile iron
LUAD
lipid peroxidation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.719187/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.719187/full

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