GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation

GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation

Background & Aims: ACE2, a carboxypeptidase that generates Ang-(1-7) from Ang II, is highly expressed in the lung, small intestine and colon. GPBAR1, is a G protein bile acid receptor that promotes the release of the insulinotropic factor glucagon-like peptide (GLP)-1 and attenuates intestinal i...

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Bibliographic Details
Main Authors: Michele Biagioli, Silvia Marchianò, Rosalinda Roselli, Cristina Di Giorgio, Rachele Bellini, Martina Bordoni, Eleonora Distrutti, Bruno Catalanotti, Angela Zampella, Luigina Graziosi, Annibale Donini, Stefano Fiorucci
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
ACE2
intestinal inflammation
SARS-CoV-2
bile acids
GPBAR1
GLP-1
Online Access:https://www.mdpi.com/2073-4409/11/7/1187

Internet

https://www.mdpi.com/2073-4409/11/7/1187

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