PEGylation of the antimicrobial peptide LyeTx I-b maintains structure-related biological properties and improves selectivity

PEGylation of the antimicrobial peptide LyeTx I-b maintains structure-related biological properties and improves selectivity

The biological activity of antimicrobial peptides and proteins is closely related to their structural aspects and is sensitive to certain post-translational modifications such as glycosylation, lipidation and PEGylation. However, PEGylation of protein and peptide drugs has expanded in recent years d...

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Bibliographic Details
Main Authors: Júlio César Moreira Brito, Lucas Raposo Carvalho, Amanda Neves de Souza, Guilherme Carneiro, Paula Prazeres Magalhães, Luiz Macêdo Farias, Natália Rocha Guimarães, Rodrigo Moreira Verly, Jarbas Magalhães Resende, Maria Elena de Lima
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
PEGylation
antimicrobial peptide
LyeTx I-b
structure
post-translational modification
peptide-membrane interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1001508/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.1001508/full

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