Hypermutator strains of Pseudomonas aeruginosa reveal novel pathways of resistance to combinations of cephalosporin antibiotics and beta-lactamase inhibitors.

Hypermutator strains of Pseudomonas aeruginosa reveal novel pathways of resistance to combinations of cephalosporin antibiotics and beta-lactamase inhibitors.

Hypermutation due to DNA mismatch repair (MMR) deficiencies can accelerate the development of antibiotic resistance in Pseudomonas aeruginosa. Whether hypermutators generate resistance through predominantly similar molecular mechanisms to wild-type (WT) strains is not fully understood. Here, we show...

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Bibliographic Details
Main Authors: Augusto Dulanto Chiang, Prashant P Patil, Lidia Beka, Jung-Ho Youn, Adrien Launay, Robert A Bonomo, Pavel P Khil, John P Dekker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-11-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001878

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https://doi.org/10.1371/journal.pbio.3001878

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