Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver

Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver

The expression of phase-I drug metabolizing enzymes in liver changes dramatically during postnatal liver maturation. Farnesoid X receptor (FXR) is critical for bile acid and lipid homeostasis in liver. However, the role of FXR in regulating ontogeny of phase-I drug metabolizing genes is not clear. H...

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Bibliographic Details
Main Authors: Lai Peng, Stephanie Piekos, Grace L. Guo, Xiao-bo Zhong
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Drug metabolizing enzymes
Farnesoid X receptor
Liver
Ontogeny
Fxr-null mouse
Gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383516301551

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http://www.sciencedirect.com/science/article/pii/S2211383516301551

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