Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas

Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas

The spatial organisation of diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) remains to be investigated. Here, the authors integrate short-read and long-read spatial profiling of DMG and GBM to identify regulatory programs and cellular ecosystems in distinct glioma niches.

Bibliographic Details
Main Authors: Yanming Ren, Zongyao Huang, Lingling Zhou, Peng Xiao, Junwei Song, Ping He, Chuanxing Xie, Ran Zhou, Menghan Li, Xiangqun Dong, Qing Mao, Chao You, Jianguo Xu, Yanhui Liu, Zhigang Lan, Tiejun Zhang, Qi Gan, Yuan Yang, Tengyun Chen, Bowen Huang, Xiang Yang, Anqi Xiao, Yun Ou, Zhengzheng Su, Lu Chen, Yan Zhang, Yan Ju, Yuekang Zhang, Yuan Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36707-6

Internet

https://doi.org/10.1038/s41467-023-36707-6

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