PTEN Inhibition Protects Against Experimental Intracerebral Hemorrhage-Induced Brain Injury Through PTEN/E2F1/β-Catenin Pathway

PTEN Inhibition Protects Against Experimental Intracerebral Hemorrhage-Induced Brain Injury Through PTEN/E2F1/β-Catenin Pathway

Intracerebral hemorrhage (ICH) is a subtype of stroke with highest mortality and morbidity. We have previously demonstrated that dipotassium bisperoxo (picolinato) oxovanadate (V), (bpV[pic]) inhibits phosphatase and tensin homolog (PTEN) and activates extracellular signal-regulated kinase (ERK)1/2....

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Bibliographic Details
Main Authors: Dan Zhao, Xing-Ping Qin, Song-Feng Chen, Xin-Yu Liao, Jing Cheng, Rui Liu, Yang Lei, Zhi-Feng Zhang, Qi Wan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
intracerebral hemorrhage
PTEN
bpV[pic]
E2F1
β-catenin
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00281/full

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https://www.frontiersin.org/article/10.3389/fnmol.2019.00281/full

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