Vaccine-Induced Antibodies Mediate Higher Antibody-Dependent Cellular Cytotoxicity After Interleukin-15 Pretreatment of Natural Killer Effector Cells

Vaccine-Induced Antibodies Mediate Higher Antibody-Dependent Cellular Cytotoxicity After Interleukin-15 Pretreatment of Natural Killer Effector Cells

The secondary analyses for correlates of risk of infection in the RV144 HIV-1 vaccine trial implicated vaccine-induced antibody-dependent cellular cytotoxicity (ADCC) responses in the observed protection, highlighting the importance of assessing such responses in ongoing and future HIV-1 vaccine tri...

Full description

Bibliographic Details
Main Authors: Leigh Fisher, Melissa Zinter, Sherry Stanfield-Oakley, Lindsay N. Carpp, R. Whitney Edwards, Thomas Denny, Zoe Moodie, Fatima Laher, Linda-Gail Bekker, M. Juliana McElrath, Peter B. Gilbert, Lawrence Corey, Georgia Tomaras, Justin Pollara, Guido Ferrari
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
antibody-dependent cellular cytotoxicity
HIV vaccine trial
interleukin-15
natural killer cells
HIV-1 infectious molecular clone-infected target cell assay
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02741/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02741/full

Similar Items