ER Stress Activating ATF4/CHOP-TNF-α Signaling Pathway Contributes to Alcohol-Induced Disruption of Osteogenic Lineage of Multipotential Mesenchymal Stem Cell

ER Stress Activating ATF4/CHOP-TNF-α Signaling Pathway Contributes to Alcohol-Induced Disruption of Osteogenic Lineage of Multipotential Mesenchymal Stem Cell

Background/Aims: Studies have provided substantial evidence that osteoblasts and adipocytes share common progenitor‒multipotential mesenchymal stem cells in bone marrow (BMSCs), and excessive alcohol consumption shifts away from osteogenic to adipogenic lineage. However, how exactly alcoh...

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Bibliographic Details
Main Authors: Yueping Chen, Hui Gao, Qingshui Yin, Liang Chen, Panfeng Dong, Xiaoyun Zhang, Jie Kang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Ethanol
Multipotential mesenchymal stem cells (MSC)
Bone-marrow stem cells (BMSCs)
Osteogenesis
Adipogenesis
Reactive oxygen species (ROS)
ER stress
Heat shock protein
ATF4
CHOP
TNF-α
Online Access:http://www.karger.com/Article/FullText/354476

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http://www.karger.com/Article/FullText/354476

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