NOD-scid IL2R γ<sup>null</sup> mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways
<p>Abstract</p> <p>Background</p> <p>Animal models of human inflammatory diseases have limited predictive quality for human clinical trials for various reasons including species specific activation mechanisms and the immunological background of the animals which markedl...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2013-01-01
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| Series: | Journal of Translational Medicine |
| Online Access: | http://www.translational-medicine.com/content/11/1/4 |