NOD-scid IL2R γ<sup>null</sup> mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways

NOD-scid IL2R γ<sup>null</sup> mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways

<p>Abstract</p> <p>Background</p> <p>Animal models of human inflammatory diseases have limited predictive quality for human clinical trials for various reasons including species specific activation mechanisms and the immunological background of the animals which markedl...

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Bibliographic Details
Main Authors:	Zadeh-Khorasani Maryam, Nolte Thomas, Mueller Thomas D, Pechlivanis Markos, Rueff Franziska, Wollenberg Andreas, Fricker Gert, Wolf Eckhard, Siebeck Matthias, Gropp Roswitha
Format:	Article
Language:	English
Published:	BMC 2013-01-01
Series:	Journal of Translational Medicine
Online Access:	http://www.translational-medicine.com/content/11/1/4

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