GalNAc-T14 may Contribute to Production of Galactose-Deficient Immunoglobulin A1, the Main Autoantigen in IgA Nephropathy

GalNAc-T14 may Contribute to Production of Galactose-Deficient Immunoglobulin A1, the Main Autoantigen in IgA Nephropathy

Introduction: Immunoglobulin A1 (IgA1) with galactose-deficient O-glycans (Gd-IgA1) play a key role in the pathogenesis of IgA nephropathy (IgAN). Mucosal-tissue infections increase IL-6 production and, in patients with IgAN, are often associated with macroscopic hematuria. IgA1-secreting cell lines...

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Bibliographic Details
Main Authors: Jana Jemelkova, Milada Stuchlova Horynova, Petr Kosztyu, Katerina Zachova, Josef Zadrazil, Dana Galuszkova, Kazuo Takahashi, Jan Novak, Milan Raska
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Kidney International Reports
Subjects:
GalNAc-T14
IgA nephropathy
IL-6 cytokine
inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024923011695

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http://www.sciencedirect.com/science/article/pii/S2468024923011695

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