Osteocytic Connexin Hemichannels Modulate Oxidative Bone Microenvironment and Breast Cancer Growth

Osteocytic Connexin Hemichannels Modulate Oxidative Bone Microenvironment and Breast Cancer Growth

Osteocytes, the most abundant bone cell types embedded in the mineral matrix, express connexin 43 (Cx43) hemichannels that play important roles in bone remodeling and osteocyte survival. Estrogen deficiency decreases osteocytic Cx43 hemichannel activity and causes a loss in osteocytes’ resistance to...

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Bibliographic Details
Main Authors: Yi Tian, Manuel A. Riquelme, Chao Tu, Yumeng Quan, Xiaowen Liu, Lu-Zhe Sun, Jean X. Jiang
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
Cx43 hemichannels
breast cancer bone metastasis
oxidative stress
estrogen deficiency
Online Access:https://www.mdpi.com/2072-6694/13/24/6343

Internet

https://www.mdpi.com/2072-6694/13/24/6343

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