HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia

HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia

Abstract Background HIF1A (Hypoxia-Inducible-Factor 1A) expression in solid tumors is relevant to establish resistance to therapeutic approaches. The use of compounds direct against hypoxia signaling and HIF1A does not show clinical efficiency because of changeable oxygen concentrations in solid tum...

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Bibliographic Details
Main Authors: Flora Cimmino, Marianna Avitabile, Vito Alessandro Lasorsa, Annalaura Montella, Lucia Pezone, Sueva Cantalupo, Feliciano Visconte, Maria Valeria Corrias, Achille Iolascon, Mario Capasso
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Medical Genetics
Subjects:
Hypoxia inducible factor HIF1A
RNA sequencing
DNA methylation
Neuroblastoma
Online Access:http://link.springer.com/article/10.1186/s12881-019-0767-1

Internet

http://link.springer.com/article/10.1186/s12881-019-0767-1

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