Capsaicin alleviates neuronal apoptosis and schizophrenia-like behavioral abnormalities induced by early life stress

Abstract Early life stress (ELS) is associated with the later development of schizophrenia. In the rodent model, the maternal separation (MS) stress may induce neuronal apoptosis and schizophrenia-like behavior. Although the TRPV1 agonist capsaicin (CAP) has been reported to reduce apoptosis in the...

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Bibliographic Details
Main Authors: Shilin Xu, Keke Hao, Ying Xiong, Rui Xu, Huan Huang, Huiling Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Schizophrenia
Online Access:https://doi.org/10.1038/s41537-023-00406-4