Discriminative Dissolution Method Using the Open-Loop Configuration of the USP IV Apparatus to Compare Dissolution Profiles of Metoprolol Tartrate Immediate-Release Tablets: Use of Kinetic Parameters

Discriminative Dissolution Method Using the Open-Loop Configuration of the USP IV Apparatus to Compare Dissolution Profiles of Metoprolol Tartrate Immediate-Release Tablets: Use of Kinetic Parameters

The use of the USP IV apparatus (flow-through cell) has gained acceptance in recent years due to its versatility and ability to discriminate due to its hydrodynamic conditions. Therefore, the objective of the present study was to develop a discriminative dissolution method in the USP IV apparatus us...

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Bibliographic Details
Main Authors: Bruno Solis-Cruz, Daniel Hernandez-Patlan, Elvia A. Morales Hipólito, Guillermo Tellez-Isaias, Alejandro Alcántara Pineda, Raquel López-Arellano
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceutics
Subjects:
USP IV apparatus
open-loop configuration
dissolution profiles
kinetic parameters
generic drugs
similarity
Online Access:https://www.mdpi.com/1999-4923/15/9/2191

Internet

https://www.mdpi.com/1999-4923/15/9/2191

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