Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response

Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response

Monomethyl fumarate (MMF), metabolite of dimethyl fumarate (DMF), an immunosuppressive drug approved for the treatment of multiple sclerosis (MS), is a potent agonist for hydroxycarboxylic acid receptor 2 (HCAR2), eliciting signals that dampen cell activation or lead to inflammation such as the skin...

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Bibliographic Details
Main Authors: Benedetta Parodi, Alessia Sanna, Alessia Cedola, Antonio Uccelli, Nicole Kerlero de Rosbo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
dimethyl fumarate
hydroxycarboxylic acid receptor 2
experimental autoimmune encephalomyelitis
dendritic cells
intestinal epithelial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.655212/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.655212/full

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