TIM-3 Expression Level on AML Blasts Correlates With Presence of Core Binding Factor Translocations Rather Than Clinical Outcomes

TIM-3 Expression Level on AML Blasts Correlates With Presence of Core Binding Factor Translocations Rather Than Clinical Outcomes

BackgroundT-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) expresses on leukemic stem and progenitor populations of non-M3 acute myeloid leukemia (AML) as well as T lymphocytes. TIM-3 is thought to be involved in the self-renewal of leukemic stem cells and the immune escape of AM...

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Bibliographic Details
Main Authors: Jian Hong, Leiming Xia, Zhenqi Huang, Xiaodong Yuan, Xinglin Liang, Jifei Dai, Zhonghui Wu, Li Liang, Min Ruan, Zhangbiao Long, Xin Cheng, Xiaowen Chen, Jing Ni, Jian Ge, Qingsheng Li, Qingshu Zeng, Ruixiang Xia, Yi Wang, Mingzhen Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
TIM-3
acute myeloid leukemia
core binding factor translocation
prognosis
flow cytometry
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.879471/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.879471/full

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