SIRT3 activation promotes enteric neurons survival and differentiation

Abstract Enteric neuron degeneration has been observed during aging, and in individuals with metabolic dysfunction including obesity and diabetes. Honokiol, a naturally occurring compound, is an activator of Sirtuin-3 (SIRT3) that has antioxidant activity. Its role in modulating enteric neuron-speci...

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Bibliographic Details
Main Authors: Arun Balasubramaniam, Ge Li, Anita Ramanathan, Simon Musyoka Mwangi, C. Michael Hart, Jack L. Arbiser, Shanthi Srinivasan
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-26634-9