Aberrant sorting of hippocampal complex pyramidal cells in type I lissencephaly alters topological innervation

Layering has been a long-appreciated feature of higher order mammalian brain structures but the extent to which it plays an instructive role in synaptic specification remains unknown. Here we examine the formation of synaptic circuitry under cellular heterotopia in hippocampal CA1, using a mouse mod...

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Bibliographic Details
Main Authors: James A D'Amour, Tyler Ekins, Stuti Ganatra, Xiaoqing Yuan, Chris J McBain
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/55173