Mitochondrial respiratory chain protein co-regulation in the human brain

Mitochondrial respiratory chain protein co-regulation in the human brain

Mitochondrial respiratory chain (RC) function requires the stoichiometric interaction among dozens of proteins but their co-regulation has not been defined in the human brain. Here, using quantitative proteomics across three independent cohorts we systematically characterized the co-regulation patte...

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Bibliographic Details
Main Authors: Caroline Trumpff, Edward Owusu-Ansah, Hans-Ulrich Klein, Annie J. Lee, Vladislav Petyuk, Thomas S. Wingo, Aliza P. Wingo, Madhav Thambisetty, Luigi Ferrucci, Nicholas T. Seyfried, David A. Bennett, Philip L. De Jager, Martin Picard
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Heliyon
Subjects:
Mitochondrial respiratory chain
Post-mortem brain
Alzheimer disease
Proteomics
ROSMAP
BLSA
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022006417

Internet

http://www.sciencedirect.com/science/article/pii/S2405844022006417

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