Naringenin Induces ROS-Mediated ER Stress, Autophagy, and Apoptosis in Human Osteosarcoma Cell Lines

Osteosarcoma, a primary bone tumor, responds poorly to chemotherapy and radiation therapy in children and young adults; hence, as the basis for an alternative treatment, this study investigated the cytotoxic and antiproliferative effects of naringenin on osteosarcoma cell lines, HOS and U2OS, by usi...

Full description

Bibliographic Details
Main Authors: Chiang-Wen Lee, Cathy Chia-Yu Huang, Miao-Ching Chi, Kuan-Han Lee, Kuo-Ti Peng, Mei-Ling Fang, Yao-Chang Chiang, Ju-Fang Liu
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/27/2/373