Natural polymers as potential P-glycoprotein inhibitors: Pre-ADMET profile and computational analysis as a proof of concept to fight multidrug resistance in cancer

Natural polymers as potential P-glycoprotein inhibitors: Pre-ADMET profile and computational analysis as a proof of concept to fight multidrug resistance in cancer

P-glycoprotein (P-gp) is known as the ''multidrug resistance protein'' because it contributes to tumor resistance to several different classes of anticancer drugs. The effectiveness of such polymers in treating cancer and delivering drugs has been shown in a wide range of in vitr...

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Bibliographic Details
Main Authors: Kumaraswamy Gandla, Fahadul Islam, Mehrukh Zehravi, Anandakumar Karunakaran, Indu Sharma, M. Akiful Haque, Sanjay Kumar, Kumar Pratyush, Sachin A. Dhawale, Firzan Nainu, Sharuk L. Khan, Md Rezaul Islam, Kholoud Saad Al-Mugren, Falak A. Siddiqui, Talha Bin Emran, Mayeen Uddin Khandaker
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Heliyon
Subjects:
Toxicity
Molecular docking
P-glycoprotein
In silico-ADMET
Natural polymers
MDR
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023066628

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http://www.sciencedirect.com/science/article/pii/S2405844023066628

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